The Fallout universe is a post-apocalyptic world set in a retro-futuristic America.
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Super mutant
Super mutant is a general term referring to humanoid mutants created by exposing a regular human to a variety of the Forced Evolutionary Virus (FEV). The resulting hulking mutants typically possess exceptional strength, endurance, resistance or immunity to disease and radiation, as well as modified intelligence. A common trait of all super mutants is that they are completely sterile and cannot reproduce (one variety is even explicitly asexual, i.e. devoid of primary sexual characteristics).
Ghouls
Ghouls are living creatures mutated by radiation, rather than killed by it. The mutation process, referred to as ghoulification, has different effects depending on the species and individual circumstances. In humans, this typically results in an extended lifespan, if not functional immortality, real-time regeneration of wounds allowing for reattaching limbs,[1] and immunity to direct damage resulting from irradiation.
Human
Are the dominant species of the post–apocalyptic age. The word is specifically used to denote those unaffected by radiation as opposed to mutants like ghouls and super mutants.